GSJ: Received Mar. 1, 2007: http://wbabin.net/saba/saba67.htm

Efficient and accurate genetic alteration is arguably the paramount objective in molecular biology and medicine.

Herein is disclosed a novel means of altering the genome of an animal or plant wherein exogenous nucleic acid is affixed to a male gamete prior to fertilization. Upon fertilization the affixed exogenous nucleic acid is engulfed with the male gamete into the ovum.

Said nucleic acids could be DNA, RNA, or a derivative thereof (such as peptide nucleic acids). Furthermore, they may be single or double stranded or a combination thereof, and of any molecular weight.

While not to limit the scope of the invention, the nucleic acids couldfunction in a permanent fashion such as a protein-encoding DNA integrated into the host DNA or on a sustainable plasmid, ortransiently such as a mRNA.

Association of the nucleic acids is preferably achieved in vitro by mixing with male gametes, or in vivo by placing the nucleic acid into the vagina.

Affixing the exogenous nucleic acid may or may not involve other molecules. For example, bispecific antibodies directed to the nucleic acid and sperm surface protein could be used. Of course any bispecific molecule which recognizes the nucleic acid (or a modification thereof) and male gamete could be used. Note, a molecule, perhaps a relatively small molecule, which binds the male gamete could be covalently bound to the nucleic acids.

If it should be that the above invention is indeed novel any patentable rights I may have, I freely give away.

It is hoped that others will honor the invention as delineated above and by the following claim.