While contemplating the prior paper, it has surprisingly been discovered that in a very general sense, one can fabricate a library of ligand combinations, particular those arrayed, simply by addressing different ligand-conjugated oligos to different and adjacent capture probes.

Figure 1 depicts the concept using arrays.

Of course any number and any kind of ligand-conjugated oligos could be addressed to an array locus given the appropriate capture probes.

Figure 2 depicts solution version of the invention, which is similar yet patentably distinct from Neri, et al (6).

Discussion as to the use of these libraries and individual members thereof can be found in

Ligand-Conjugated Polynucleotides and Microarrays of Combinatorial Libraries Thereof

Reference: