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Email: James Saba
James Saba

All patentably novel ideas, discovered and described in the following papers by James Saba, are completely free!

In that this journal is exclusively electronic, it is recommended that you print out and file the articles you are interested in. This is particularly important to establish date of conception of the molecular biology inventions.

Particle Physics:

Added Jun. 27, 2007: Particle Rest Mass as Electrostatic Potential Energy
Added Jun. 6, 2007: The Spins of the Pion and Muon, in Light of Neutrinos being Photon-Like
Added May 2, 2007: Fermi Lab MiniBooNE Neutrino Experiment Does Not Support Neutrino Oscillation or Mass
Added Apr. 11, 2005: Contacting a Positron and an Isolated Neutron may result in a Proton and Gamma Ray
Added Dec. 22, 2004: A Two Particle System without Integer Spin
Added Aug. 8, 2003: Implications of Dirac's Monopoles for Color Charged Particles of the New Quark Theory
Updated Oct. 16, 2002: Alternative to Direct Proton-Proton Fusion in Deuterium Formation
Updated Apr. 30, 2002: Simplification and Unification of Fundamental Particles

Molecular Biology:

Added Jul. 29, 2007: Antiparallel Microtubule Sliding During Mitosis
Added Jul. 26, 2007: Protein Libraries via Noncovalent mRNA Display, and the Screening Thereof
Added Jul. 18, 2007: On-Chip Synthesis of Aptamer Microarrays
Added Jul. 13, 2007: Influenza Vaccine Comprising a Universal Live-attenuated Virus Combined With a Variable Surface Antigen Encoding Nucleic Acid
Added Jul. 8, 2007: Polynucleotides Containing Cross-linked Nucleotides as Immunosuppressors
Added Jul. 2, 2007: Multiple Primer-producing Rolling Circle Amplification
Added Jun. 23, 2007: Libraries and the Screening thereof for Facilitators of Nucleic Acid Transfection
Added May 23, 2007: dATP Regenerating System and its use in the Bioluminescent Assay of Deoxynucleases or DNA
Added May 22, 2007: Isolation of Nucleic Acids via Functions of Their Encoded Enzymes
Added May 19, 2007: Discovery of Drugs Targeting the Ribosome
Added Apr. 24, 2007: Cell Type-Specific Nuclear Magnetic Resonance (NMR)
Added Apr. 18, 2007: Drug Discovery with Microarrays and Beads
Added Apr. 16, 2007: Discovery of Protease Modulators via Pyrophosphate Signaling
Added Apr. 16, 2007: Discovery of Modulators of Polymerization
Added Apr. 15, 2007: Cell Surface Receptor Ligand Discovery
Added Apr. 15, 2007: Allosteric Modulation of Drug Resistant Mutants
Added Apr. 9, 2007: Ingestible Nucleic Acids as Insecticides
Added Mar. 2, 2007: Vaccines Comprising Small Molecule Regulated Death Genes
Added Mar. 1, 2007: Genetic Engineering by Association of Nucleic Acids with Sperm
Added Feb. 28, 2007: Induction of Immunological Tolerance by Positioning Antigen-expressing Nucleic Acids in Thymus
Added Nov. 2, 2006: Microchip Motion Detector to Prevent Sudden Infant Death Syndrome
Added Mar. 8, 2006: Novel Vaccination Process: Preliminary Induction of Immunological Tolerance to Major Epitopes
Added Mar. 2, 2006: A Two-Step Antibody Directed Targeting of Cells, Viruses or Nucleic Acids
Added Mar. 1, 2006: A Universally Applicable Three Step Antibody Directed Enzyme Prodrug Therapy (ADEPT)
Added Feb. 27, 2006: Monoclonal Antibody Therapy Utilizing Proximity-Based Liberation of Coupled Toxin
Added Feb. 27, 2006: Receptor Crosslinking Utilizing Different Monoclonal Antibodies
Added Jan 5, 2005: Ligand Receptor Discovery Utilizing Radiolabeled Ligands, Microarrays, and Radiosensitive Materials
Added Jul. 12, 2005: 'Combinatorial' Epitope Formed by a Ligand and its Target Binding Site
Added Jul. 9, 2005: Allosteric Exposure of Sequestered HIV Epitopes
Added Jul. 1, 2005: Oral Drugs which Direct an Immediate Antibody Response to a Resistant Virus or Cell
Added Jun. 27, 2005: Combinatorial Libraries of Beads, Viruses and/or Cells
Added Jun. 24, 2005: Nucleic Acid Amplifications utilizing Polymers or Particles Conjugated with Multiple Primers
Added Jun. 8, 2005: Supramolecular Constructs Comprising Addressable DNA-conjugated Proteins
Added Jun. 6, 2005: Libraries of Encoded beads, each Member Noncovalently Associated with Multiple Identical Molecules, Viruses or Cells
Added Jun. 5, 2005: Molecules Which Only Recognize Ligand-Bound Receptors
Added Jun. 4, 2005: Identifying Proteins which Stereoselectively Bind a Drug via a Cell Surface Expression Library
Added Jun. 3, 2005: Isolation of Enantiomer-binding Proteins, via Microarrays or Beads, and Scintillation Proximity
Added Jun. 2, 2005: High Density Protein Microarrays via Addressing to Arrayed Peptide
Added Jun. 1, 2005: Microarrays for Discovering Allosteric Ligands of Enzymes
Added Jun. 1, 2005: Allosteric Drug Discovery Utilizing Microarrayed Ligands
Added May 31, 2005: Allosteric Restoration or Expansion of Mutator Phenotypes of Microbial Polymerases
Added May 29, 2005: Phage Display Libraries in Affinity-based Screenings for Molecules which Induce or Disrupt Molecular Associations
Added May 19, 2005: Isolating Antibodies with Modulative Affinity via Phage Display
Added May 18, 2005: Whole Genome Amplification Utilizing Nick Displacement Amplification
Added May 18, 2005: Detection and Analysis of Nucleic Acids Utilizing Microarrays and Rolling Circle Amplification (RCA)
Added May 16, 2005: Immunoassays and Arrayassays Utilizing Oligonucleotide-conjugated Antibodies
Added May 13, 2005: Alternatives to Southern Hybridization and in situ Hybridization
Added May 8, 2005: Proteins Whose Function is Modulated by Ligands or Enzymes
Added May 8, 2005: Homogeneous One-Pot Immunoassays Utilizing Complement C1 and Fluorogenic Peptide Substrate
Added Apr. 21, 2005: Fluorescent Detection of Nucleic Acids via Self-Quenched Probes
Added Apr. 18, 2005: Real-time Polymer Labeling via Incorporation of FRET Dye-conjugated Monomers Adjacent to One Another
Added Apr. 16, 2005: Triple Hybrid Structure Derivations
Added Apr. 16, 2005: Exceedingly Simple, Target Sequence-Stablized, Latent Primers
Added Apr.15, 2005:Detection, Characterization and/or Quantitation of Support-Affixed Nucleic Acid Sequences via Rolling Circle Amplification (RCA)
Added Apr. 9, 2005: Spatially Localized Exponential Rolling Circle Amplification (RCA)
Updated Feb 24, 2005: Functional Screening Utilizing an Arrayed Library of Clonally Expanded Cells, Viruses, or Nucleic Acids
Added Feb 9, 2005: Microarrays of Ligand Combinatorial Libraries Utilizing Mixtures of Addressable Probes at Each Locus
Added Feb 8, 2005: Polyethylene Glycol (PEG) Conjugates and Optionally Arrayed Libraries thereof for Separations, Analyses and Therapeutics
Added Feb 1, 2005: Lysogenic Bacteria, Capable of Therapeutic Virus Liberation Subsequent to Tumor Cell Targeting
Added Jan. 27, 2005: Targeted Therapeutic Nucleic Acids, Derived From Libraries of Chimeric Nucleic Acids Which Encode Cis-Binding Proteins
Added Jan. 25, 2005: Microarray of Polypeptides, via Simultaneous in vitro Translation of Arrayed mRNAs.
Added Jan. 18, 2005: DNA Amplifications Utilizing Unnatural Base-Pairs and an DNA/RNA Polymerase
Added Jan. 14, 2005: A Novel Isothermal Nucleic Acid Amplification Resulting in a Spatially Localized Product
Added Jan. 9, 2005: A Novel Isothermal Nucleic Acid Amplification, Rolling Circle Chain Reaction
Updated Jun. 21, 2004: Ligand-Conjugated Polynucleotides and Microarrays of Combinatorial Libraries Thereof
Added May 18, 2004: An Isothermal Nucleic Acid Amplification (Nick Displacement Amplification)
Added Oct. 19, 2003: Microfluidic Protein Sequencing II
Added Sep. 21, 2003: Micro Mass Spectrometric Protein Sequencing
Added Sep. 16, 2003: Microfluidic Protein Sequencing
Added Jun.19, 2002: Matrix Sequencing - DNA